Yi-Kuen Lee (PhD, UCLA, 2001)

 

                                    Associate Professor in Mechanical Engineering and Biomedical Engineering, HKUST, Hong Kong

                                    Associate Director of the Institute of Integrated Microsystem (I2MS)

                                    Associate Director of Center for Bioengineering & Biomedical Devices

                                    Co-Director, KAUST-HKUST Micro/Nanofluidics Laboratory

                                               Tel: +852 2358-8663, +852 2358-7206 (Lab), Fax: +852 2358-1543

                                     E-mail: meyklee @ ust.hk

Dr. Lee
graduated from Department of Bio-Industrial Mechatronics Engineering (formerly Department of Agricultural Machinery Engineering), National Taiwan University (NTU), Taiwan with honor, and then obtained MS degree in Institute of Applied Mechanics, NTU.  After completing two-year military service in Taiwan, he went to the United State and obtained Ph.D. degree in Mechanical Engineering with Microelectromechanical System (MEMS) major from the University of California, Los Angeles (UCLA). He was an assistant professor in Department of Mechanical Engineering from 2001 to 2007. Since 2007, he is Associate Professor and the Associate Director of Institute of Integrated Microsystems (I2MS), Co-Director of KAUST-HKUST Micro/Nanofluidics Laboratory, Associate Director of Center for Bioengineering & Biomedical Devices. He is also Faculty Affiliate in the Division of Biomedical Engineering at the Hong Kong University of Science and Technology (HKUST), Hong Kong. In addition, he is a Visiting Associate in Caltech Micromachining Laboratory, California Institute of Technology, USA.

Major Research Interests:

  • Bio-Microelectromechanical System (Bio-MEMS) and Lab-on-a-chip: micro biosensors, micro electroporation chips, micro electroosmosis and electrophoresis chip modified by self-assembled monolayer (SAM), micro MEKC separation chip
  • Micromechanics and Nanomechanics 
  • NEMS (Nanoelectromechanical System) and Nanobiotechnology:  branch of Nanotechnology
  • Microfluidics/nanofluidics: micro chaotic mixing, spatial-temporal chaotic mixer, micro bubble actuators for integrated microfluidic systems.
  • MEMS key technology development: ICP Deep RIE process modeling and optimization using Design of Experiments.
  • Micro inertial sensors: integrated accelerometers, micro gyroscopes.
  • Micro biometric sensor: fingerprint sensor
  • Fluorescence microscopy for single DNA molecule dynamics in micro/nanofluidics

Dr. Lee's Research Lab homepage: http://ihome.ust.hk/~microsys

Professional Affiliation:

·    American Society of Mechanical Engineering (ASME)  MEMS Division

·    Hong Kong Society of Theoretical and Applied Mechanics (HKSTAM)

·    Institute of Electrical and Electronics Engineers (IEEE)  

·    Taiwan Instiute of Biological Mechatronics  

 

Graduate/Post-doc Admission:

Students with strong background on microelectronics fabrication, mechanical engineering, molecular and cellular biology are welcome to join our MEMS research at HKUST. Please follow the HKUST General Graduate Admission. Application Deadline  Admission FAQ   New MECH PhD program with Nanotechnology Concentration.

Post-doctoral researchers and visiting scholars with highly motivated mind and good English communication skill are also welcome to join our MEMS/NEMS research at HKUST. Please send CV to me by email. 

Book Chapters

P. Cheng, Y.K. Lee and P. Deng, Thermal Bubbles in Encyclopedia of Micro- and Nano-Fluidics, D. Li (ed.), Springer, 2008.

P. Tabeling and Y.K. Lee, “Micro/nanofluidic Processes,” in Micro/Nano Technology Systems for Biomedical Applications: Microfluidics, Optics, and Surface Chemistry, Chapter 2, C.M. Ho (ed.), pp.33,52, Oxford University Press, 2010.

Journal Paper Publications  

    1. Y.-K. Lee, “Lyapunov Exponents of a Micro Chaotic Mixer,” International Journal of Nonlinear Sciences and Numerical Simulation,  Vol. 3, No.3-4,              

         pp.561-563, 2002. Abstract 

    2.  P.K. Wong, Y.-K. Lee and C.M. Ho, “Deformation of DNA Molecules by Hydrodynamic Focusing",  Journal of Fluid Mechanics, Vol. 497, pp.55-65, 2003. 

           Abstract

     3.  X. Niu, Y.-K. Lee, "Efficient Spatial-temporal Chaotic Mixing in Microchannels," Journal of Micromechanics and Microengineering, Vol. 13, No. 3, 

           pp.454-462, 2003.  Abstract

     4.  P. Deng, Y.-K. Lee, P. Cheng, "The Growth and Collapse of a Micro-bubble under Pulse Heating," International Journal of Heat and Mass Transfer,  

          Vol. 46, No.21, pp.4041-4050, 2003. Abstract

    5.  A.S.W. Ng, W.L.W. Hau, Y.-K. Lee and Y. Zohar, "Electrokinetic Generation of Microvortex Patterns in a Microchannel Liquid Flow,"  Journal of 

           Micromechanics and Microengineering, Vol. 14, No. 2, pp.247-255, 2004. Abstract  

     6. P. Deng, Y.-K. Lee and P. Cheng, "Micro Bubble Dynamics in DNA solutions,"  Journal of Micromechanics and Microengineering, Vol. 14, No. 5, pp.  

          693-701, 2004.  Abstract  

     7.  A. Dodge, M.-C. Jullien, Y.-K. Lee, X. Niu, F. Okkels, and P. Tabeling, "An example of a chaotic micromixer: the channel-micromixer" Comptes 

          Rendus Physique (one journal of French Academy of Science),Vol. 5, No. 5, pp. 557-563,  2004.

     8. A.I.K. Lao, Y.-K. Lee and I.M. Hsing, "Mechanistic  Investigation of Nanoparticle Motion in Pulsed Voltage Miniaturized Electrical Field Flow Fractionation 

         by In-Situ Imaging of Nanoparticle Motion,"  Analytical Chemistry,  Vol. 76, No. 10, pp.2719-2724, 2004. Abstract

     9. P. Deng, Y.-K. Lee and P. Cheng, "Measurements of Micro Bubble Nucleation Temperatures in DNA Solution,"  Journal of Micromechanics 

          and Microengineering  Vol. 15, No.3, pp.564-574, 2005.   Abstract

    10. T.F. Yu, Y.-K. Lee, M. Wong and Y. Zohar, "Fluid Flow in Microchannels with Cavities,"  Journal of Microelectromechanical Systems

          (J MEMS), Vol. 14, No.6, pp.1-14, 2005.  Abstract

    11. M. Lee, L.S.L. Cheung, Y.-K. Lee and Y. Zohar, "Height Effect on Nucleation-Site Activity and Size-Dependent Bubble Dynamics in Microchannel 

           Convective Boiling," Journal Micromechanics and Microengineering, Vol. 15, No. 11, pp.1-9, 2005.  Abstract

    12. H. He, D. C. Chang and Y.-K. Lee, "Micro Pulsed Radio-Frequency Electroporation Chip," Bioelectrochemistry, Vol. 68, No.1, pp. 89-97, 2006. Abstract.

    13.  P. Deng, Y.-K. Lee and P. Cheng, "Two-dimensional Micro Bubble Actuator Array to Enhance the Efficiency of Molecular Beacon Based DNA Micro 

           Biosensor,"  Biosensors and Bioelectronics, Vol. 21, No. 8, pp. 1443-1450, 2006.   Abstract 

    14. L.M. Lee, W. L.W. Hau, Y.-K. Lee, Y. Zohar, "In-plane Vortex Flow in Microchannels Generated by Electroosmosis with Patterned Surface Charge," 

          Journal of Micromechanics and Microengineering, Vol. 16, No. 1, pp.17-26, 2006.  Abstract

    15.  X. Niu, W. Wen and Y.-K. Lee, “Electrorheological-fluid-based Microvalves,” Applied Physics Letters, Vol. 87, 243501 (1-3), 2005. Abstract

    16. P. Deng, Y.-K. Lee and P. Cheng, "An Experimental Study of Heater Size Effect on Micro Bubble Generation,"  Intl. J. Heat and Mass Transfer, Vol. 49,

          No. 15-16,  pp.2535-2544, 2006.

    17. Z. Jia, Y.-K. Lee, Q. Fang and C. W. Huie, "Video Imaging of Sample Zone Narrowing and Dispersion in a Glass Microchip: the Effect of Organic Solvent

          (Acetonitrile)-salt Mixtures in the Sample Matrix and Surfactant Micelles in the Running Buffer," Electrophoresis , Vol. 27, No.5-6, pp.1104-1111, 2006.

    18. Y. C. Chan, Y.-K. Lee and Y. Zohar, "High-throughput Design and Fabrication of an Integrated Microsystem with High Aspect-Ratio Sub-Micron Pillar 

          Arrays for Free-Solution Micro Capillary Electrophoresis," Journal of Micromechanics and Microengineering, Vol. 16, No. 4, pp. 699-707, 2006.

    19. B. Xu, Y.-K. Lee, Q.H. Jin, J.L. Zhao and C.M. Ho, "Multi-layer SU-8 Microdispenser for Microarray Assay," Sensors and Actuators A: Physical,

          Vol. 132, No. 2,  pp. 714-725, 2006.

    20. H. He, D. C. Chang and Y.-K. Lee, "Using a Micro Electroporation Chip to Determine the Optimal Physical Parameters in the Uptake of Biomolecules in 

          HeLa Cells," Bioelectrochemistry, Vol. 71, No. 2, pp.363-368, 2007.

    21. X. Cao, W.-J. Chiang, Y.-C. King and Y.-K. Lee, "Electromagnetic Energy Harvesting Circuit With Feedforward and Feedback DC-DC PWM Boost

          Converter for Vibration Power Generator System," IEEE Transactions on Power Electronics, Vol. 22, No. 2, pp. 679-685, 2007.

  

    22. Y.-K. Lee, L.M. Lee, W.L.W. Hau and Y. Zohar., “Two-Dimensional Analysis of Electrokinetically-driven Out-of-plane Vorticies in a Microchannel Liquid Flow Using        

          Patterned Surface Charge,” Journal of Microelectromechanical Systems, Vol. 16, No. 1, pp.58-67, 2007.

    23. Y.-K. Lee, C. Shih, P. Tabeling and C.M. Ho, “Experimental Study and Nonlinear Dynamic Analysis of Time-periodic Micro Chaotic Mixers,” Journal of Fluid 

           Mechanics, Vol. 575, pp.425-448, 2007.

    24. H. He, D.C. Chang and Y.-K. Lee, “Nonlinear Current Response of Micro Electroporation and Resealing Dynamics for Human Cancer Cells,” Bioelectrochemistry,

Vol. 72, No. 2, pp.161-168, 2008.

25.  Y.-Y. Ling, Y. Zhang, W. Wen, P. Tabeling and Y.-K. Lee, “An Integrated Micro Giant Electrorheological Fluid Valves for Micro Flow Cytometry,” Journal of Micro/

Nanolithography, MEMS and MOEMS, Vol. 8, No. 2, 021103, 2009.

26.     Y.C. Chan, Y. Zohar and Y.-K. Lee, “Effects of Embedded Sub-Micron Pillar Arrays in Microfluidic Channels on Large DNA Electrophoresis,” Electrophoresis,

Vol. 30, No. 18, pp.3242-3249, 2009.

27.     B.J. Xu, Z.B. Liu, J.J. Yu, Y.-K. Lee and M. Yang , A PDMS Microfluidic System with Poly (ethylene glycol)/SU-8 Based Apertures for Planar Whole Cell Patch-Clamp Recordings,

Sensors and Actuators A, 2009 (dx.doi.org/10.1016/j.sna.2009.12.010).

28.     L. Chen, Z. Xiao, P.C.H. Chan, Y.-K. Lee, “Static and Dynamic Characterization of Robust Superhydrophobic Surfaces Built from Nano-flowers on Silicon Micro-Post Arrays,”

        Journal Micromechanics and Microengineering, Vol. 20. No. 10,  105001 (8pp), 2010 (dx.doi.org/10.1088/0960-1317/20/10/105001).

29.     S. Sun, G. Yin, Y.-K. Lee, J.T.Y. Wong, T.-Y. Zhang, “Effects of deformability and thermal motion of lipid membrane on electroporation: By molecular dynamics simulations,” Biochemical and Biophysical Research Communications, Vol. 404, No. 2, 684-688, 2011.

30.     S. Wang, K. Liu, J. Liu, Y.-K. Lee, Z T.-F. Yu, E.K. Lee, X. Xu, J. Reiss, L.W.K. Chung, J. Huang, M. Rettig, A. Pantuck, D. Silegson, K.N. Duraiswamy, C.K.-F. Shen and H.-R.  

        Tseng, “Highly Efficient Capture of Circulating Tumor Cells Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers,” Angewandte Chemie International 

        Ed., Vol.50 pp.3084-3088, 2011 (http://dx.doi.org/10.1002/anie.201005853): Selected as the cover page in the issue of 21 Mar 2011.

    31.   W. Wang, Y.C. Chan and Y.-K. Lee, “Biased Reptation Model with Electroosmosis for DNA Electrophoresis in Microchannels with Sub-Micron Pillar Array,” Journal of Micromechanics and

Microengineering, 2011 (http://dx.doi.org/10.1088/0960-1317/21/8/085031).

    32.    L. Chen, Z. Xiao, P. C. H. Chan, Y.-K. Lee, and Z. Li, "A Comparative Study of Droplet Impact Dynamics on a Dual-scaled Superhydrophobic Surface and Lotus Leaf," Applied Surface Science, 2011.

    33.    R. Lin, D.C. Chang and Y.-K. Lee, “Single-Cell Electroendocytosis on a Micro Chip Using In Situ Fluorescence Microscopy,” Biomedical Microdevices, Vol. 13, No. 6, 1063,1073, 2011.

34.   M. Lee, L.S.L. Cheung, Y.-K. Lee and Y. Zohar, "Design, Fabrication and Characterization of a Thermal Microsystem Integrated with Pressure and Temperature Microsensors," Journal of

        Micromechanics and Microengineering, Vol. 21, No. 12, 125021, 2011 (http://dx.doi.org/10.1088/0960-1317/21/12/125021).

35.   M. Lee, Y.-K. Lee and Y. Zohar, “Single-phase liquid flow forced convection under nearly uniform heat flux boundary condition in microchannels,” Journal of Micromechanics and Microengineering, 2011 (in review).

36.   R. Lin, D.C. Chang and Y.-K. Lee, “Temperature-Dependent Single-Cell Endocytosis on a Micro System,” Lab on a Chip, 2011 (in review).

Conference Presentations:

   1. Y.-K. Lee, C. Shih, P. Tabling, C.M. Ho, “Characterization of Mixing Process in a Microchannel Flow,” presented at 52-th Annual Meeting of American

          Physical Society, Division of Fluid Dynamics (APS-DFD),  New Orleans, LA, USA, Nov 21-23, 1999.

   2. Y.K. Lee, U.C. Yi, F.G. Tseng, C.J. Kim and C.M. Ho,   “Fuel Injection by a Thermal Microinjector,”  Proceedings of MEMS,  ASME International Mechanical 

         Engineering, Nashville, Tennessee, USA, pp. 419-425. Nov 14-19, 1999. Abstract

   3.  Y.-K. Lee, P. Tabeling, C. Shih and C.M. Ho, “Characterization of a MEMS-Fabricated Mixing Device,” Proceeding of MEMS, ASME International 

         Mechanical Engineering Congress and Exposition, Orlando, Florida, Nov 5-10, pp.505-511, 2000. Abstract

   4. Y.-K. Lee, J. Deval, P. Tabeling, and C.M. Ho, “Chaotic Mixing in Electrokinetically Pressure Driven System Flows,”  IEEE 14th International Conference on

         Micro Electro Mechanical System (MEMS 2001), Interlaken, Switzerland, pp.483-486, 2001.  Abstract 

   5. P.K. Wong, Y.-K. Lee, C.H. Ho, “Dynamics of DNA Molecules in Microchannel Flow,” presented at 2nd University of California-wide Bioengineering  

        Symposium, May 6-7, 2001.  

    6. Y.-K. Lee, J. Deval, C.M. Ho, P. Tabeling, "Chaotic Mixing in Electrokinetically and Pressure Driven Micro Flows," IMRET 5: Proc. of the 5th International. 

        Conference on Microreaction Technology, Strasbourg, France (Springer-Verlag, Berlin, 2002), May 27-30, pp.185-191, 2001.

    7. Y.-K. Lee, A.S.W. Ng, L.M. Lee, Y. Zohar, “Micro Vortex Generation in Microchannel Liquid Flow,” presented at 55-th Annual Meeting American Physical     

         Society, Division of Fluid Dynamics, Nov. 24-26, Dallas, TX, USA, 2002.

    8. Y. Zohar, Z.T.F. Yu, Y.-K. Lee, "Hele-Shaw Flow in a Microchannel with Cavities," presented at 55-th Annual Meeting of American Physical Society, 

        Division of Fluid Dynamics, Nov. 24-26, Dallas, TX, USA,  2002.

    9. W.L.W. Hau, L.M. Lee, Y.-K. Lee, M. Wong and Y. Zohar, "Experimental Investigation of Electrokinetically Generated In-Plane Vorticity in a Microchannel," 

        Transducers'03 (the 12th Intl. Conf. on Solid-State Sensors, Actuators and Microsystems), Boston, USA, Jun 8-12, Vol.1, pp.651-654, 2003. Abstract . 

    10. A. S. W. Ng, W.L.W. Hau, Y.-K. Lee and Y. Zohar, "Numerical Simulations of Electrokinetically Generated Micro Vortices in Microchannels," Transducer'03 

        (the 12th Intl. Conf. on Solid-State Sensors, Actuators and Microsystems), Boston, pp.1887-1890, 2003. Abstract . 

    11. P. Deng, Y.-K. Lee and P. Cheng, "Design and Characterization of A Micro Single Bubble Actuator ,"  Transducer'03 (the 12th Intl. Conf. on Solid-State 

           Sensors, Actuators and Microsystems), Boston, pp.647-650, 2003. Abstract. 

    12. X. Niu, Y.-K. Lee, "Finite Time Lyapunov Exponent for Micro Chaotic Mixer Design ," ASME IMECE'03, Washington DC, Nov. 16-21, 2003 

           (IMECE2003-41389). Abstract

    13. W.L.W. Hau, L.M. Lee, Y.-K. Lee and Y. Zohar, "Electrically Driven Vortical Motion for Mixing of Liquids in a Microchannel ," Micro TAS 2003, Oct 5-9,     

          Squaw Valley, California, USA, pp. 491-494, 2003. Abstract. 

    14. P.K. Wong, T.H. Wang, Y.-K. Lee, C. Shih and C.M. Ho, “Visualization of Nanoscale Biomolecules in Micro Fluidic Devices," presented at the 7th Asian 

           Symposium on Visualization, May 26-30, Singapore, 2003.

    15.  A. I.K. Lao, T.P. Duan, Y.-K. Lee and I.M. Hsing, "Microfabricated Flow Fractionation Device Assisted by a Pulse Electric Field: In-situ Visualization and 

            its Application for DNA Separation," American Institute of Chemical Engineers 2003 Annual Meeting, Nov. 16-21, San Francisco, CA, USA.

    16. M. Lee, L.S.L. Cheung, Y.-K. Lee, M. Wong, Y. Zohar, "Height Effect on Nucleation-Site Activity in Microchannel Convective Boiling,"  IEEE MEMS 2004, 

          Maastricht, Netherlands, Jan 25-29, pp.300-303, 2004, Abstract

    17. Z.T.F. Yu, Y.-K. Lee, M. Wong, Y. Zohar, "Size-Dependent Flow Separation in Microchannels with Cavities," IEEE MEMS 2004, Maastricht, Netherlands,  

          Jan  25-29, pp.296-299, 2004, Abstract.

    18. P. Deng, Y.-K. Lee and P. Cheng, "Viscosity Effect on Micro Bubble Actuator in ssDNA Solutions," IEEE MEMS 2004, Maastricht, Netherlands, Jan 

          25-29, pp.292-295, 2004,  Abstract.

    19. P. Deng, Y.-K. Lee and P. Cheng, "Characterization of an Integrated Self-sensing Submicron Bubble Actuator," Asia-Pacific Conf. of 

          Transducers and Micro-Nano Tech. (APCOT), Sapporo, Japan, July 4-7, pp. 310-315, 2004. Abstract.

    20. Y.-K. Lee, "Complex Electroosmotic Microflow with Surface Charge Patterning," The 7th Asian Conference on Analytical Sciences (Asianalysis VII), July

           28-31, 2004 (invited).

    21. F. Yang, H. He, D.C. Chang and Y.-K. Lee, "Parametric Study of Pulsed Radio-Frequency Electroporation on Microchip at the Single-cell Level," 

          The 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Micro TAS 2004), Malmö, Sweden, 26-30 Sep, Vol. 2, pp. 79-81, 

          2004. Abstract.

    22. Y.-K. Lee, "Electrokinetic Vortex Dynamics in Surface Charge Patterned Microchannels," The 6th World Congress of Computational Mechanics (WCCM 

          VI), Beijing, China, 2004 (invited).

    23. M. Lee, Y.-K. Lee, M. Wong and Y. Zohar, "Fabrication and Characterization of an Integrated Thermal Microsystem," IEEE MEMS 2005, 

          Miami, FL, USA, pp.610-613, 2005.  Abstract

    24. L. M. Lee, Y.-K. Lee and Y. Zohar, "Unsteady In-Plane Vortex Motion in a Microchannel Liquid Flow,"  IEEE MEMS 2005, Miami, pp.734-737, 2005. 

          Abstract 

    25. L.S.L. Cheung, Y.-K. Lee, M. Wong and Y. Zohar, "Size-Dependent Bubble Dynamics in a Microchannel Heat Sink," IEEE MEMS 2005, 

          Miami, FL, USA, pp.670-673, 2005. Abstract

    27. P. Deng, Y.-K. Lee and P. Cheng, "Scaling Effects of Micro Bubble Actuators," Transducers 2005, Seoul,  Korea, Vol. 2, pp. 1267-1271, Jun 5-9, 2005. 

          Abstract

     28. X. Niu, Weijia Wen and Y.-K. Lee, "Micro Valves Using Nanoparticles-based Giant Electrorheological Fluid," Transducers 2005, Seoul,  

           Korea, Vol. 1, pp.652-655, 2005. Abstract

     29. E.K.L. Chan, C.K.Y. Wong, M. Lee, M.M.F. Yuen, Y.-K. Lee, "Using PDMS Micro-transfer Moulding for Polymer Flip Chip Packaging on MEMS," the 55th 

            Electronic Components and Technology Conference (ECTC), Lake Buena Vista, FL, USA, May 31-June 3, pp.1071-1076, 2005.

     30. Y.-K. Lee and P. Deng, "Bubble Actuator Enhanced DNA Micro Biosensor,"  Proceeding of the 2005 IEEE International Conference on Robotics and 

           Biomimetics ( IEEE Robio'05), Hong Kong and Macau, pp.752-756, Jun 29-Jul 3, 2005. Abstract

     31. Y. C. Chan, Y.-K. Lee, M. Wong and Y. Zohar, "High-Throughput Fabrication of Sub-Micron Pillar Arrays for Free-Solution DNA Electrophoresis without 

           E-beam Lithography," Proceeding of the 2005 IEEE International Conference on Robotics and Biomimetics (IEEE Robio'05), Hong Kong and Macau, 

           pp.101-104, Jun 29-Jul 3, 2005. Abstract

     32. W.L.W. Hau, P.K Leung, L.M. Lee, Y.-K. Lee and Y. Zohar, "Electrokinetically-Driven Micro Mixer with a Novel Surface-Charge Pattern ," Proceeding of 

           the 2005 IEEE International Conference on Robotics and Biomimetics (IEEE Robio'05), Hong Kong and Macau, pp.783-787, Jun 29-Jul 3, 2005.

     33. H. He, D.C. Chang and Y.-K. Lee, "Large-Scale Parametric Study of Electroporation in Cancer Cells to Construct Phase Diagrams Using Micro Cell-Array 

            Chips," The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (Micro TAS 2005), Boston,  USA, pp.382-384, Oct 9-13, 2005. 

            Abstract

     34. Y.C. Chan, Y.-K. Lee, M. Wong and Y. Zohar, "Effect of Sub-Micron Pillar Array on DNA Kinetics in a Free-Solution Capillary Electrophoresis 

           Microsystem," Micro TAS 2005, Boston,  USA, pp.337-339, Oct 9-13, 2005. Abstract

     35. C.W. Huie, Q. Li, Z. Jia, Y.-K. Lee, Q. Fang and Z.L. Fang, "Effect of Organic Solvent-Salt Mixtures on Sample Preconcentration in Capillary and Microchip 

           Electrophoresis," The 8th Asian Conference on Analytical Science (Asianalysis VIII), Taipei, Taiwan, Oct 16-20, 2005.

     36. M. Lee, Y.-K. Lee and Y. Zohar, "Two-Phase Flow in Microchannel Heat Sink with Nearly Uniform Heat Flux Boundary Condition," IEEE NEMS 2006, Zuhai, 

            China,  Jan 18-21, pp. 754-758, 2006.

     37. P.K. Leung, P. Deng, Y.-K. Lee, "Comparative Study of Size Effect of Micro Bubble Dynamics by Sub-100 Microsecond and Milisecond Pulse Heating," IEEE 

           NEMS 2006, Zhuhai, China, Jan 18-21, pp.525-529, 2006.

     38. X. Niu, Y.-K. Lee, Liyu Liu and W. Wen, "Micro valve and chaotic mixer driven by electrorheological fluid," IEEE NEMS 2006, Zhuhai, China, Jan 18-21, 

           pp.1254-1257,  2006.

     39. Y.C. Chan, Y.-K. Lee  and Y. Zohar, "Nonlinear Electrophoretic Mobility of Large DNA Molecules in Microsystem with Sub-Micron Pillar 

           Arrays,"  IEEE MEMS 2006, Istanbul, Turkey, pp.438-441,  Jan 22-26, 2006.

     40. M. Lee, L.S.L. Cheugn, Y.-K. Lee and Y. Zohar, "Boundary Conditions and Integrated Sensors in Microchannel Convective Heat Transfer," the 4th International 

           Conference on Nanochannels, Microchannels and Minichannels (ASME ICNMM 2006), Limerick, Ireland, June 19-21, 2006 (No. ICNMM2006-96117) (keynote 

          paper). 

     41. X. Cao and Y.-K. Lee, "Design and Fabrication of Mini Vibration Power Generator," IEEE International Conference on Information Acquisition (IEEE ICIA 2006), 

           Weihai, China, pp.91-95, Aug 20-23, 2006.

     42. H. He, Y.-K. Lee and D.C. Chang, "Molecular Size Effect on Micro Electroporation by Using Microchip with a Three-dimensional Electrode Array," The 10th 

           International Conference on Miniaturized Systems for Chemistry and Life Sciences (Micro TAS 2006), Tokyo, Japan, pp.28-30, 2006.

     43. H. He, D.C. Chang and Y.-K. Lee, "Nonlinear Transmembrane Current Response of Micro Electroporation for Human Cancer Cells," IEEE NEMS 2007, Bangkok, 

           Thailand, pp.258-262, Jan 16-19, 2007.

     44. M. Lee, Y.-K. Lee and Y. Zohar, "The Nusselt Number in Single-Phase Liquid Flow Forced Convection in Microchannels ," IEEE NEMS 2007, Bangkok, Thailand, 

          pp.502-506, Jan 16-19, 2007.

     45. M. Lu, A. Bermak, Y.-K. Lee, "Fabrication Technology of Piezoresistive Conductive PDMS for Micro Fingerprint Sensors," IEEE MEMS 2007, Kobe, Japan, 

           pp.251-254, Jan 21-25,  2007.

     46. Y.C. Chan, Y.-K. Lee and Y. Zohar, "Pillar Size Effect on DNA Electrophoresis in Microchip with Sub-micron Pillar Arrays," IEEE MEMS 2007, Kobe, Japan, 

           pp.413-416, Jan 21-25, 2007.

     47. M. Lee, Y.-K. Lee and Y. Zohar, "Two-Phase Flow Oscillations in Microchannel Convective Boiling," IEEE MEMS 2007, Kobe, Japan, pp.635-638, Jan 21-25, 2007.

     48. J. Lu, M. Lu, A. Bermak and Y.-K. Lee, “Study of Piezoresistance Effect of Carbon Nanotube-PDMS Composite Materials for Nanosensors,” IEEE Nano 2007,

           Hong Kong, pp.1240-1243, Aug 2-5, 2007.

     49. Y.Y. Ling, Y. Zhang, W. Wen, P. Tabeling and Y.-K.  Lee, “Design and Fabrication of Integrated Micro GER Valves for Micro Flow Cytometry,” Asia-Pacific

Conference on Transducers and Micro-Nanotechnology (APCOT 2008), Tainan, Taiwan, 22-25 Jun 2008.

     50. K.-Y. Fong, R. Lin, P. Tabeling and Y.-K. Lee, “A Droplet-Based Real-Time PCR Microchip with Self-Sening Heaters for Bacterial Detection,” IEEE NEMS 2009, pp.143-146,

Shenzhen, China, Jan 5-8, 2009.

     51. H. He, D.C. Chang and Y.-K. Lee, “Battery-Powered Miniaturized Electroporation System for In-Situ Gene Transfer in Stem Cell Research, IEEE NEMS 2009, pp. 458-462,

Shenzhen, China, Jan 5-8, 2009.

     52. B.J. Xu, Z.B. Liu, J.J. Yu, Y.-K. Lee and M. Yang , “A PDMS Planar Patch-Clamp Array Chip with Poly (Ethylene Glycol)/SU-8 Based Cell-Patch Interface, IEEE

MEMS 2009, Sorrento, Italy, pp.395-398, 25-29 Jan 2009.

     53. L. Chen, Z. Xiao, P.C.H. Chan and Y.-K. Lee, “Dual-Scaled Superhydrophobic Nano-Flower Surfaces,” 15th International Conf. on Solid-State Sensors, Actuators and

Microsystems (Transducers 2009), Denver, CO, USA, pp.441-444, 21-25 Jun 2009.

     54. R. Lin, D.C. Chang and Y.-K. Lee, “Study of Single-Cell Electroendocytosis Using Bio-MEMS Technology,” 15th International Conf. on Solid-State Sensors, Actuators

and Microsystems (Transducers 2009), Denver, CO. USA, pp.2366-2369, 21-25 Jun 2009.

     55. G.-Y. Yin, R. Lin, T.-Y. Zhang, D.C. Chang and Y.-K. Lee, “Systematic Study of Electroporation of Mouse Myoblast Cells on Microchips,”  the 13th International

Conference on Miniaturized Systems for Chemistry and Life Sciences, Jeju, Korea, pp.509-511, 1-5 Nov 2009.

     56. L. Chen and Y.-K. Lee, “New Dimensionless Number for Superhydrophobicity Study of Micron/Submicron Patterned Surfaces,” 23rd IEEE International Conference

on Micro Electro Mechanical Systems (IEEE MEMS 2010), Hong Kong, pp.1051-1054, 24-28 Jan 2010.

     57. P. Deng, G. Yin, T.-Y. Zhang, D.C. Chang and Y.-K. Lee, “Theoretical and Experimental Study of Electroporation of Red Blood Cells Using MEMS Technology,” the

5th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010), Xiamen, China, pp.588-591, 20-23 Jan 2010.

     58. X. Jiang, Y. Ling, C. Liu, S. Yang and Y.-K. Lee, “Electrorheological Characterization of Ultrathin Titanium Dioxide Nanorod Solutions Using Microfluidics,” the

5th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010), Xiamen, China, pp.362-365, 20-23 Jan 2010.

     59. W. Wang, Y.C. Chan and Y.-K. Lee, “Biased Reptation Model with Electroosmosis for DNA Electrophoresis in Microchannels with Sub-Micron Pillar Array,” the

5th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010), Xiamen, China, pp.425-428, 20-23 Jan 2010.

     60. Y. Ling, H. Liu and Y.-K. Lee, “A Micro Flow Cytometry System for Study of Marine Phytoplankton from Costal Waters of Hong Kong,”  the 5th Annual IEEE

International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2010), Xiamen, China, pp.580-583, 20-23 Jan 2010.

     61. R. Lin, D. C. Chang, and Y.-K. Lee, "Temperature Effect on Single-Cell Electroendocytosis Using a Cell-Array Chip with Micro Temperature Sensors and a

           Peltier Thermoelectric Device," 2010 International Symposium on Microchemistry and Microsystems (ISMM 2010), Hong Kong, pp. 47-48, 28-30 May, 2010.

     62. W. Wang and Y.-K. Lee, "Optimum Peclet Numbers for Accurate Measurement of Electroosmotic Mobility of Complex DNA Buffers in Micro/Nanofludics," 

           the 14-th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'10), pp.1766-1768, Groningen, Netherlands, 3-7 Oct, 2010.

     63. R. Lin, D. C. Chang, and Y.-K. Lee, "Study of Temperature Effect on Single-Cell Fluid-Phase Endocytosis Using Micro Cell Chips and Thermoelectric Devices,"

          the 14-th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'10), pp.962-964, Groningen, Netherlands, 3-7 Oct, 2010.

     64. H. Shagoshtasbi and Y.-K. Lee, “A New Equivalent Circuit Model for Micro Electroporation Systems,” the 6th IEEE International Conference on Nano/Micro

Engineered and Molecular Systems (IEEE NEMS '11), pp.697-700, Kaohsiung, Taiwan, Feb 20-23, 2011.

     65. P. Deng, J. Zhou, G. Li, D.C. Chang and Y.-K. Lee, “DNA Transfection of Bone Marrow Mesenchymal Stem Cells Using Micro Electroporation Chips,”

           the 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS '11), pp.98-101, Kaohsiung, Taiwan, Feb 20-23, 2011.

     66. B. Lu, J.C-H. Lin, Z. Liu, Y.-K. Lee and Y.-C. Tai, “Highly Flexible, Transparent and Patternable Parylene-C Superhydrophobic Films with High and Low Adhesion,”   

          IEEE MEMS 2011, pp.1143-1146, Cancun, Mexico, 23-27 Jan 2011.

     67. J. C.-H. Lin, G. Lam, B. Lu, P. Deng, Y.-K. Lee, Y.-C Tai, “Creep of Parylene C-Film,” the 16th International Conference on Solid-State Sensors, Actuators and

Microsystems (Transducers’11), pp.2698-2701, Beijing, China, Jun 5-9, 2011.

     68. W. Wang and Y.-K. Lee, "Unified Theory to Evaluate the Effect of Concentration Difference and Peclet Number on Electroosmotic Mobility Error of Micro

           Electroosmotic Flows," the 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS '12), Kyoto, Japan 2011 (accepted).

     69. R. Lin, D. C. Chang, and Y.-K. Lee, "The Effect of Cytochalasin D on F-Actin Behavior of Single-Cell Electroendocytosis Using Multi-Chamber Micro Cell Chip,"

          the 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS '12), Kyoto, Japan 2011 (accepted).

 

  Patent:

·    C.M. Ho, P. Tabeling, J.H. Deval, "A Micro Chaotic Mixer", US Patent 6,9023,313, 2005.

·    J.L Zhao, B.J. Xu, Q.H. Jin, Y.K. Lee, C.M. Ho, “Design and fabrication of a microdispenser for microarray assay”, China Patent No. CN1629319, 2005

·    Q.H. Jin, B.J. Xu, J.L. Zhao, M.M. Yang, Y.K. Lee, C.M. Ho, “A device of fabricating biochip with moderate and low throughput microarray”, China Patent No. CN1719257, 2006.

 

 Professional Affiliation:

·    American Society of Mechanical Engineering (ASME)  MEMS Division

·    Hong Kong Institution of Engineers (HKIE), Member

·    Hong Kong Society of Theoretical and Applied Mechanics (HKSTAM)

·    Institute of Electrical and Electronics Engineers (IEEE)  

             IEEE Hong Kong Chapter

 

 Research Grants:

 

  • HKUST Direct Allocation Grant 2001/2002,  Active micromixer - a building block for integrated (PI).
  • HKUST I2MS Grant 2002-2004, Fabrication and Characterization of Micromixers,  HKUST (PI).
  • HK RGC CERG 2002-2005, Micro thermal bubble actuators to enhance DNA hybridization (PI).
  • HK RGC CERG 2002-2003, Integrated free-solution electrophoresis microsystems for DNA separation (PI).
  • HK RGC CERG 2003-2004, Complex electroosmotic flows in microchannels with patterned surface  (Co-I).
  • HK RGC CERG 2004-2006, Integrated nano bubble actuator (PI).
  • HK RGC CERG 2005-2006, Low-Voltage Micro Pulsed RF Electroporation Cell Chip for DNA Transfer  (PI).
  • HK RGC CERG 2006-2007, Nonlinear Electrophoresis Dynamics of Large DNA Molecules in Micro Electrophoresis Chip with Nanopillar Arrays (PI)
  • HK RGC CERG 2007-2008, Microelectroendocytosis Cell Chips for DNA Transfection with High Cell Viability (PI)
  • KAUST-HKUST 2008-2012, Joint Microfluidics Research Project on micro electroporation (Co-I)
  • HK RGC CERG 2007-2008, The TiO2-modified UV-C Disinfection Process for Inhibition of Post-Irration Bacteria Recovery: Mechanism Assessment and Process

                Development (Co-I, with Prof Chii Shang, HKUST)

  • HK RGC CERG 2007-2008, An Integrated Microfluidic Chip for Single Cell Electrophysiological Studies within Picoliter Volume (Co-I, with Prof Mo Yang, HK PolyU).
  • HKUST Emerging High Impact Areas (EHIA) Grant 2005/06, Integrated Smart Biometrics Systems (Co-I, with Prof Amine Bermak).
  • HKUST Emerging High Impact Areas (EHIA) Grant 2005/06, Novel DNA-Aptamer based Bioanalytical Microsystem (Co-I, with Prof I-Ming Hsing)
  • USA Natl Sci. Foundation Intl. Grant 2003~2007, Microfluidic Mixers Using Nanoengineered Responsive Polymer Surfaces (PI, with Prof Qiao Lin, Carnegie Mellon Univ., USA).
  • HKUST Research Travel Grant 2003, HKUST (PI).
  • HKUST PDF Matching Fund 2002-2003, Low-Pressure and Medium-Pressure UV/Monochloramine Disinfection Microbial Inactivation and By-Product Formation (Co-I).
  • HKUST PDF Matching Fund 2004-2005, Micro and Submicron Thermal Bubble Actuator to enhance DNA Hybridization (PI).
  • HKUST Direct Allocation Grant 2004/2005,  Scaling of micro bubble actuator devices (PI).
  • HKUST PDF Matching Fund, 2005-2006, Development of technology for integrated nano bubble actuator devices (PI).
  • F-HK17/02T 2002/2004  France/Hong Kong Joint Research Scheme, Chaotic Mixing in Microsystems (PI, Co-I: Prof Patrick Tabeling, ESPCI, France).
  • F-HK18/05T 2006/2007  France/Hong Kong Joint Research Scheme,  Integrated Microfluidic System Using Giant Electrorheological Fluid , with  Prof Patrick Tabeling, ESPCI,

        Paris, France (PI).

  • F-HK07/08.EG07 2007/2008 France/Hong Kong Joint Research Scheme, Giant Electrorheological Fluid Based-Digital Microfluidics, with Prof Patrick Tabeling, ESPCI,

        Paris, France (PI).

 

 

 Research Collaboration:

·    Prof Patrick Tabeling, MMN, ESPCI,  Paris, France.

·    Prof Chih-Ming Ho, UCLA

·    Prof Yu-Chong Tai, Caltech

·    Prof Donald Chang, HKUST; Prof Tong-Yi Zhang, HKUST

·    Prof Ya-Pu Zhao, State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China

·    Prof Jianlong Zhao, SIMIT, Shanghai, China, Prof Kevin Fan-Gang Tseng, Natl. Tsing Hua Univ., Hsin-Chu, Taiwan, ROC.

·    Prof Ya-Chin King, Dept. of Electrical Engineering, National Tsing Hua University, Hsin-Chu, Taiwan, ROC.

·    Prof Qiao Lin, Biofluidic Micro Systems Lab, Dept. of Mechanical Engineering, Columbia University, New York, NY, USA.

·    Prof Chiang Shih, Department of Mechanical Engineering, Florida State University, Tallahassee, Florida, USA.

 

 

Course taught:

·    MECH103 Mechanisms and Dynamics of Machinery, Fall 2008

·    MECH106, Fall 2008

·    MECH300G Mechanical Vibrations,  Spring 2008

·    MECH597 (MECH691Q) Advanced Microsystem Technology, Fall 2005

·    MESF 595: Introduction of Microsystem: Technology and Devices, Spring 2007

·    IBTM 556: Vibration and Mechanical Signature Analysis, Spring 2008

       

 

Academic services:

·     Reviewer for Journal of Micromechanics and Microengineering, Institute of Physics (JMM)

·     Reviewer for ASME/IEEE Journal of Microelectromechanical System (JMEMS)

·     Reviewer for Sensors and Actuators A, Elsevier  (S&A A)

·     Reviewer for Microfluidics and Nanofluidics, Springer

·     Reviewer for ASME Journal of Fluid Engineering (JFE)

·     Reviewer for Europhysics Letters, European Physical Society

·     Reviewer for Measurement Science and Technology, Institute of Physics (MST)

·     Reviewer for Biosensors and Bioelectronics, Elsevier

 

·     General Co-Chair of IEEE NEMS 2006, Zhuhai, China, Jan 18-21, 2006

·     Member of Technical Program Committee of IEEE MEMS 2007, Kobe, Japan, Jan 21-25, 2007

·     Member of Technical Program Committee of IEEE NEMS 2007, Bangkok, Thailand, Jan 16-19, 2007

·     Member of Technical Program Committee of IEEE Nano 2007, Hong Kong, Aug 2-5, 2007

·     Member of Program Committee for IEEE ICMA 2007, Harbin, China, Aug  5-8, 2007

·     Member of Program Committee for Asia-Pacific Conference of Transducers and Micro-Nanotechnology (APCOT 2008), Tainan, Taiwan, Aug  22-25, 2008

·     Member of Technical Program Committee for ASME MicroNano 2008 (ASME Integration and Commercilization of Micro and Nanosystems), Hong Kong, Jun 2-5, 2008

·     Member of Technical Program Committee of IEEE NEMS 2009, Shenzhen, China, Jan 5-8, 2009

·     Member of Technical Program Committee of IEEE NEMS 2010, Xiamen, China, Jan 20-23, 2010

·    Member of Technical Program Committee of IEEE Transducers 2011, Beijing, China, Jan 20-23, 2011

·     Member of Technical Program Committee of IEEE NEMS 2011, Kaohsiung, Feb 20-23, 2011

·     Chair for ICMAN 2011, Shenzhen, 5-8 Nov 2011.

·     Member of Technical Program Committee of IEEE NEMS 2012, Kyoto, Japan, Mar 5-8, 2012

·     Member of Technical Program Committee of APCOT, Nanjing, China, Jul 8-11, 2012

·     Member of Scientific Committee, Microfluidics 2012, EMBL Heidelberg, Germany, Dec 3-5, 2012

 

Interesting Links:

·    HKUST VLSI Homepage

·    Small Times

·    NanoApex

·    MEMS Clearing House

·    MEMS-talk mailing list

 

Conferences:

·    ICMAN 2011, Shenzhen, China, 5-8 Nov 2011

·    IEEE MEMS 2012, Paris, France, 29Jan – 2 Feb 2012. (Lionel , Abstract deadline: 14 Sep 2010.

·    IEEE NEMS 2012, Kyoto, Japan, 5-8 Mar 2012

·    APCOT 2012, Nanjing, China, 8-11 July 2012 (Abstract: 15 Jan 2012)

·    MicroTAS 2012, Okinawa, Japan, 28 Oct-1 Nov 2012 (Abstract: 15 Apr 2012)

·    Transducers 2013, Barcelona, Spain, 16-20 Jun 2013.

·    iCAN 2011 (the 2nd International Contest of Applications in Nano/Micro Technologies), Beijing, 5-9 Jun 2011

 

 

Travel around the World

          

Direction to HKUST:

 

     Transportation information 

 

        HKUST campus map    

 

        HKUST on-campus Hotel: Visitor Center, Hong Kong Hotel Reservation Service, Asia Travel

 

 

Number of Visitors    since Sep 2, 2002

 

 

26 Nov 2011 updated